Drug Interactions

Silodosin is metabolised mainly by cytochrome P450 3A4 (CYP3A4), UDP-glucuronosyltransferases (UGTs), alcohol dehydrogenase (ADH), and aldehyde dehydrogenase (ALDH).

Co-administration with potent inhibitors of CYP3A4 activity blocks the metabolism of silodosin. This may result in elevated plasma drug concentrations.

Silodosin (Urief®) should be administered with care when co-administered with the following drugs.

Drugs Signs, Symptoms, and
Treatment
Mechanism and Risk
Factors
Hypotensive agents Since orthostatic hypotension may occur, attention should be paid to dosage reduction, etc. Patients receiving treatment with a hypotensive agent may have diminished ability to regulate blood pressure on standing.
Azole anti-fungal agents Itraconazole, etc. Elevated plasma concetrations of silodosin have been reported following coadministration with ketoconazole ( oral preparation not marketed in Japan), a potent CYP3A4 inhibitor. Since elevated plasma concentrations of silodosin may occur following coadministration with
azole antifungal agents, attention
should be paid to dosage reduction, etc.
Since azole antifungal agents inhibit CYP3A4, elevated plasma concentrations of silodosin may occur following coadministration with these preparations.
Phosphodiesterase-5 inhibitors
Sildenafil citrate,            Vardenafil hydrochloride hydrate etc.
It has been reported that symptomatic hypotension may occur in concomitant use of these drugs. Since silodosin has an α-blocking effect, co-administration may enhance the hypotensive effect due to the vasodilatory effect of these drugs.

 

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