- Elobixibat (GOOFICE®) exerts its inhibitory effect on P-glycoprotein.
- Precautions for Co-administration (Elobixibat (GOOFICE®) should be administered with care when co-administered with the following drugs.)
| Drugs | Signs, symptoms, and Treatment |
Mechanism and Risk factors |
| Bile acid preparations: Ursodeoxycholic acid, chenodeoxycholic acid |
The effects of these drugs may be attenuated. | The inhibitory effect of Elobixibat on ileal bile acid transporter (IBAT) may interfere with reabsorption of bile acid preparations. |
| Aluminum-containing antacids: Sucralfate hydrate, aldioxa, etc. |
These drugs may attenuate the effect of Elobixibat. | These drugs absorb bile acids in the gastrointestinal tract and may attenuate the effect of Elobixibat. |
| Cholestyramine, colestimide | These drugs may attenuate the effect of Elobixibat. | These drugs absorb bile acids and may attenuate the effect of Elobixibat. |
| Digoxin, Dabigatran etexilate methanesulfonate |
The blood levels of these drugs may elevate and possibly enhance their effects. | Because of the inhibitory effect of Elobixibat on P-glycoprotein |
| Midazolam | The blood level of midazolam may decrease, and the effect of midazolam may decrease | The mechanism is unknown. |