Drug Interactions

This product should be administered with care when co-administered with the following drugs.

Drug Name Clinical Symptoms/
Measures
Mechanism/Risk Factor
Loop diuretics
Ethacrynic acid
Furosemide, etc.
Thiazide and similar
antihypertensive diuretics
Trichlormethiazide
Chlortalidone, etc.
Since hypokalaemia (feelings of weakness, muscular weakness, etc.) might develop, adequate measures should be taken with careful observation (including determination of serum potassium level). These diuretics enhance the
potassium excreting effect of
glycyrrhizic acid contained in this product, thus tending to decrease serum potassium.
Moxifloxacin hydrochloride Ventricular tachycardia (including torsade de pointes) and QT prolongation may occur. When serum potassium
concentration decreases by the potassium-excreting effect of glycyrrhizic acid contained in this product, ventricular tachycardia (including torsade de pointes) and QT prolongation due to moxifloxacin hydrochloride
may occur.