There have been post‑marketing cases of intentional and accidental overdose in pediatric patients with doses of perampanel up to 36 mg and in adult patients with doses up to 300 mg. The adverse reactions observed included altered mental status, agitation, aggressive behaviour, coma and depressed level of consciousness. The patients recovered without sequelae.
There is no available specific antidote to the effects of perampanel.
General supportive care of the patient is indicated including monitoring of vital signs and observation of the clinical status of the patient. In view of its long half‑life, the effects caused by perampanel could be prolonged. Because of low renal clearance special interventions such as forced diuresis, dialysis or hemoperfusion are unlikely to be of value.