Pharmacodynamics

Mechanism of Action

This drug is a selective 5-HT₄ receptor agonist. It is considered that this drug stimulates 5-HT4 receptors in the gastrointestinal nerve plexus, which increases the release of acetylcholine, resulting in enhancement of gastrointestinal motility and gastric emptying.

.Clinical Pharmacology

In the gastric emptying test for healthy adults and patients with chronic gastritis, single administration of 5 mg of this drug enhanced gastric emptying.

Gastroprokinetic Effect

Gastroprokinetic effect on the stomach and duodenum

This drug increased gastric and duodenal motility after meals in conscious dogs.

Gastroprokinetic effect on the on the colon and delivery of colon content

This drug showed a dose-dependent prokinetic effect on the colon and delivery of colon content in guinea pigs.

Gastric Emptying Enhancing Effect

This drug enhances gastric emptying of liquid (in mice and rats) and solid (in rats) content. The gastric emptying enhancing effect was decreased after one week repeated administration (in rats).

Clinical Studies

The results of clinical studies on 435 cases in total including a double-blind comparative study are summarized below.